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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
Biological insertion of computationally designed short transmembrane segments
|
|---|---|
| Published in |
Scientific Reports, March 2016
|
| DOI | 10.1038/srep23397 |
| Pubmed ID | |
| Authors |
Carlos Baeza-Delgado, Gunnar von Heijne, Marc A. Marti-Renom, Ismael Mingarro |
| Abstract |
The great majority of helical membrane proteins are inserted co-translationally into the ER membrane through a continuous ribosome-translocon channel. The efficiency of membrane insertion depends on transmembrane (TM) helix amino acid composition, the helix length and the position of the amino acids within the helix. In this work, we conducted a computational analysis of the composition and location of amino acids in transmembrane helices found in membrane proteins of known structure to obtain an extensive set of designed polypeptide segments with naturally occurring amino acid distributions. Then, using an in vitro translation system in the presence of biological membranes, we experimentally validated our predictions by analyzing its membrane integration capacity. Coupled with known strategies to control membrane protein topology, these findings may pave the way to de novo membrane protein design. |
Twitter Demographics
The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 40% |
| Venezuela, Bolivarian Republic of | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 24% |
| Student > Bachelor | 4 | 10% |
| Student > Master | 4 | 10% |
| Researcher | 4 | 10% |
| Professor | 4 | 10% |
| Other | 8 | 20% |
| Unknown | 7 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 44% |
| Biochemistry, Genetics and Molecular Biology | 12 | 29% |
| Engineering | 2 | 5% |
| Chemistry | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 7 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2016.
All research outputs
#1,259,788
of 22,856,968 outputs
Outputs from Scientific Reports
#12,364
of 123,434 outputs
Outputs of similar age
#23,022
of 300,781 outputs
Outputs of similar age from Scientific Reports
#388
of 3,389 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,781 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 3,389 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.