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DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population

Overview of attention for article published in Brazilian Journal of Microbiology, April 2016
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Title
DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population
Published in
Brazilian Journal of Microbiology, April 2016
DOI 10.1016/j.bjm.2015.09.001
Pubmed ID
Authors

Ronaldo Celerino da Silva, Heidi Lacerda Alves da Cruz, Lucas André Cavalcanti Brandão, Rafael Lima Guimarães, Lilian Maria Lapa Montenegro, Haiana Charifker Schindler, Ludovica Segat, Sergio Crovella

Abstract

β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Professor 3 15%
Researcher 3 15%
Student > Bachelor 2 10%
Student > Postgraduate 2 10%
Other 4 20%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 6 30%
Biochemistry, Genetics and Molecular Biology 4 20%
Immunology and Microbiology 2 10%
Nursing and Health Professions 2 10%
Unknown 6 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2016.
All research outputs
#10,978,483
of 12,355,257 outputs
Outputs from Brazilian Journal of Microbiology
#291
of 363 outputs
Outputs of similar age
#231,303
of 275,975 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#9
of 9 outputs
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