Title |
Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients
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Published in |
Behavioral and Brain Functions, February 2012
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DOI | 10.1186/1744-9081-8-11 |
Pubmed ID | |
Authors |
Yongfeng Yang, Wenqiang Li, Jingyuan Zhao, Hongxing Zhang, Xueqin Song, Bo Xiao, Ge Yang, Chengdi Jiang, Dai Zhang, Weihua Yue, Luxian Lv |
Abstract |
Ghrelin (GHRL) is a pivotal peptide regulator of food intake, energy balance, and body mass. Weight gain (WG) is a common side effect of the atypical antipsychotics (AAPs) used to treat schizophrenia (SZ). Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI). However, it is unclear whether GHRL polymorphisms are associated with WG due to AAPs. Furthermore, there is no evidence of an association between GHRL polymorphisms and SZ or the therapeutic response to AAPs. We explored these potential associations by genotyping GHRL alleles in SZ patients and controls. We also examined the relation between these SNPs and changes in metabolic indices during AAP treatment in SZ subgroups distinguished by high or low therapeutic response. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 19% |
Student > Master | 7 | 13% |
Researcher | 6 | 12% |
Student > Doctoral Student | 3 | 6% |
Other | 3 | 6% |
Other | 6 | 12% |
Unknown | 17 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 19% |
Psychology | 8 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Agricultural and Biological Sciences | 4 | 8% |
Engineering | 2 | 4% |
Other | 6 | 12% |
Unknown | 18 | 35% |