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Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients

Overview of attention for article published in Behavioral and Brain Functions, February 2012
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Title
Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients
Published in
Behavioral and Brain Functions, February 2012
DOI 10.1186/1744-9081-8-11
Pubmed ID
Authors

Yongfeng Yang, Wenqiang Li, Jingyuan Zhao, Hongxing Zhang, Xueqin Song, Bo Xiao, Ge Yang, Chengdi Jiang, Dai Zhang, Weihua Yue, Luxian Lv

Abstract

Ghrelin (GHRL) is a pivotal peptide regulator of food intake, energy balance, and body mass. Weight gain (WG) is a common side effect of the atypical antipsychotics (AAPs) used to treat schizophrenia (SZ). Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI). However, it is unclear whether GHRL polymorphisms are associated with WG due to AAPs. Furthermore, there is no evidence of an association between GHRL polymorphisms and SZ or the therapeutic response to AAPs. We explored these potential associations by genotyping GHRL alleles in SZ patients and controls. We also examined the relation between these SNPs and changes in metabolic indices during AAP treatment in SZ subgroups distinguished by high or low therapeutic response.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Student > Master 7 13%
Researcher 6 12%
Student > Doctoral Student 3 6%
Other 3 6%
Other 6 12%
Unknown 17 33%
Readers by discipline Count As %
Medicine and Dentistry 10 19%
Psychology 8 15%
Biochemistry, Genetics and Molecular Biology 4 8%
Agricultural and Biological Sciences 4 8%
Engineering 2 4%
Other 6 12%
Unknown 18 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2012.
All research outputs
#20,880,816
of 25,654,806 outputs
Outputs from Behavioral and Brain Functions
#317
of 419 outputs
Outputs of similar age
#132,469
of 168,666 outputs
Outputs of similar age from Behavioral and Brain Functions
#7
of 8 outputs
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