Title |
Zika virus and neurologic autoimmunity: the putative role of gangliosides
|
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Published in |
BMC Medicine, March 2016
|
DOI | 10.1186/s12916-016-0601-y |
Pubmed ID | |
Authors |
Juan-Manuel Anaya, Carolina Ramirez-Santana, Ignacio Salgado-Castaneda, Christopher Chang, Aftab Ansari, M. Eric Gershwin |
Abstract |
An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 42% |
Chile | 1 | 8% |
Brazil | 1 | 8% |
Ecuador | 1 | 8% |
Colombia | 1 | 8% |
Unknown | 3 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Scientists | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 2 | <1% |
Brazil | 2 | <1% |
France | 1 | <1% |
Switzerland | 1 | <1% |
New Zealand | 1 | <1% |
United States | 1 | <1% |
Unknown | 197 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 20% |
Student > Bachelor | 31 | 15% |
Student > Master | 27 | 13% |
Student > Ph. D. Student | 21 | 10% |
Student > Doctoral Student | 15 | 7% |
Other | 45 | 22% |
Unknown | 26 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 63 | 31% |
Agricultural and Biological Sciences | 31 | 15% |
Immunology and Microbiology | 16 | 8% |
Biochemistry, Genetics and Molecular Biology | 14 | 7% |
Nursing and Health Professions | 9 | 4% |
Other | 34 | 17% |
Unknown | 38 | 19% |