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STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL

Overview of attention for article published in Acta Ortopédica Brasileira, February 2016
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Title
STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL
Published in
Acta Ortopédica Brasileira, February 2016
DOI 10.1590/1413-785220162401152960
Pubmed ID
Authors

Marcelo Ferraz de Campos, Cintia Pereira de Oliveira, Charles Benjamin Neff, Olga Maria de Toledo Correa, Maria Aparecida Silva Pinhal, Luciano Miller Reis Rodrigues

Abstract

To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model. Wistar rats underwent intervertebral disc degeneration through 20-gauge needle puncture, and 360° rotation applied for 30 sec, representing the degenerated group, while control group was not submitted to this procedure. Histological parameters and expression of extracellular matrix molecules were evaluated in the 15(th) and 28(th) days after degenerative induction. Fifteen days after the induction of intervertebral disc degeneration, significant changes were observed, such as reduction in the expression metalloprotease-9 (MMP9) and interleukins (IL-6 and IL-10). There was a significant increase in the expression of vascular endothelial growth factor (VEGF) and caspase-3. However, different alterations in the ECM were observed at 28 days, the level of collagen I, metalloprotease-2 (MMP2) and caspase-3 were enhanced. Furthermore, expression of heparanase isoforms (HPSE1 and HPSE2) mRNA were increased in the degenerative intervertebral disc. The different profiles of ECM molecules observed during the intervertebral disc degeneration suggest that molecular processes such as ECM remodeling, neovascularization, apoptosis and inflammation occur. Experimental Study.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 15%
Student > Ph. D. Student 2 15%
Student > Master 2 15%
Student > Bachelor 2 15%
Other 1 8%
Other 2 15%
Unknown 2 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 23%
Immunology and Microbiology 1 8%
Psychology 1 8%
Physics and Astronomy 1 8%
Materials Science 1 8%
Other 3 23%
Unknown 3 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2016.
All research outputs
#11,081,866
of 12,463,644 outputs
Outputs from Acta Ortopédica Brasileira
#55
of 78 outputs
Outputs of similar age
#225,024
of 268,469 outputs
Outputs of similar age from Acta Ortopédica Brasileira
#2
of 3 outputs
Altmetric has tracked 12,463,644 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 78 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.