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Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro

Overview of attention for article published in Genetics and Molecular Biology, March 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
27 Dimensions

Readers on

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40 Mendeley
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Title
Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro
Published in
Genetics and Molecular Biology, March 2016
DOI 10.1590/1678-4685-gmb-2015-0057
Pubmed ID
Authors

Bellagamba, Bruno Corrêa, Abreu, Bianca Regina Ribas de, Grivicich, Ivana, Markarian, Carolina Franke, Chem, Eduardo, Camassola, Melissa, Nardi, Nance Beyer, Dihl, Rafael Rodrigues

Abstract

Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 30%
Student > Master 8 20%
Student > Bachelor 6 15%
Researcher 3 8%
Professor > Associate Professor 1 3%
Other 1 3%
Unknown 9 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 35%
Agricultural and Biological Sciences 4 10%
Medicine and Dentistry 3 8%
Chemistry 2 5%
Immunology and Microbiology 2 5%
Other 3 8%
Unknown 12 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2016.
All research outputs
#17,328,796
of 21,448,133 outputs
Outputs from Genetics and Molecular Biology
#265
of 265 outputs
Outputs of similar age
#203,080
of 280,186 outputs
Outputs of similar age from Genetics and Molecular Biology
#3
of 7 outputs
Altmetric has tracked 21,448,133 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 265 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,186 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.