↓ Skip to main content

The importance of p53 pathway genetics in inherited and somatic cancer genomes

Overview of attention for article published in Nature Reviews Cancer, March 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
22 X users
facebook
1 Facebook page
f1000
1 research highlight platform

Citations

dimensions_citation
123 Dimensions

Readers on

mendeley
240 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The importance of p53 pathway genetics in inherited and somatic cancer genomes
Published in
Nature Reviews Cancer, March 2016
DOI 10.1038/nrc.2016.15
Pubmed ID
Authors

Giovanni Stracquadanio, Xuting Wang, Marsha D. Wallace, Anna M. Grawenda, Ping Zhang, Juliet Hewitt, Jorge Zeron-Medina, Francesc Castro-Giner, Ian P. Tomlinson, Colin R. Goding, Kamil J. Cygan, William G. Fairbrother, Laurent F. Thomas, Pål Sætrom, Federica Gemignani, Stefano Landi, Benjamin Schuster-Böckler, Douglas A. Bell, Gareth L. Bond

Abstract

Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 2%
Germany 2 <1%
Portugal 1 <1%
France 1 <1%
Unknown 232 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 41 17%
Student > Ph. D. Student 39 16%
Student > Master 33 14%
Student > Bachelor 21 9%
Professor 16 7%
Other 53 22%
Unknown 37 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 80 33%
Agricultural and Biological Sciences 48 20%
Medicine and Dentistry 40 17%
Chemistry 6 3%
Computer Science 5 2%
Other 22 9%
Unknown 39 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2017.
All research outputs
#2,833,192
of 25,559,053 outputs
Outputs from Nature Reviews Cancer
#911
of 2,480 outputs
Outputs of similar age
#44,312
of 315,211 outputs
Outputs of similar age from Nature Reviews Cancer
#13
of 41 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,480 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,211 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.