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IgG4-related disease: a systematic review of this unrecognized disease in pediatrics

Overview of attention for article published in Pediatric Rheumatology, March 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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1 blog
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Citations

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116 Dimensions

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119 Mendeley
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Title
IgG4-related disease: a systematic review of this unrecognized disease in pediatrics
Published in
Pediatric Rheumatology, March 2016
DOI 10.1186/s12969-016-0079-3
Pubmed ID
Authors

Faiz Karim, Jan Loeffen, Wichor Bramer, Lauren Westenberg, Rob Verdijk, Martin van Hagen, Jan van Laar

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition with an unclear pathophysiological mechanism affecting different parts of the body. If untreated, the disease can lead to fibrosis and irreversible organ damage. IgG4-RD mostly has been described in adults, hence it is generally unknown among pediatricians. This systematic search of the literature provides an overview of all reports published on IgG4-RD in children in order to create awareness of IgG4-RD in pediatrics and to emphasize the broad clinical presentation of this disease. A systematic literature search of Embase, Medline, Web-of-Science, PubMed publisher, Cochrane and Google Scholar was performed for case reports on IgG4-RD in children. Of total 740 articles identified by the search, 22 case reports including 25 cases of IgG4-RD in children were found. The median age of the children was 13 years, of which 64 % were girls. IgG4-related orbital disease (44 %) and autoimmune pancreatitis type 1/IgG4-related pancreatitis (12 %) predominantly occurred. Less frequently, other manifestations as pulmonary manifestation, cholangitis and lymphadenopathy were also found. Almost all cases were histologically proven. Prednisone was the first choice of treatment leading to favorable clinical response in 83 % of the cases. Maintenance therapy with steroid sparing agents was required in 43 % of the cases needing therapy. Rituximab was successful in all 4 cases, whereas, the disease modifying rheumatic drugs (DMARDs) mycophenolate mofetil, azathioprine and methotrexate were effective in almost 50 % of the cases. IgG4-RD in children is a generally unknown disease among pediatricians, but several pediatric cases have been described. Prednisone is the first choice of treatment leading to disease remission in the majority of the cases. DMARDs and rituximab are alternative effective steroid sparing agents with more positive evidence for the latter.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 119 100%

Demographic breakdown

Readers by professional status Count As %
Other 17 14%
Student > Postgraduate 15 13%
Student > Master 13 11%
Researcher 11 9%
Student > Doctoral Student 9 8%
Other 29 24%
Unknown 25 21%
Readers by discipline Count As %
Medicine and Dentistry 73 61%
Immunology and Microbiology 5 4%
Nursing and Health Professions 3 3%
Neuroscience 3 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 5 4%
Unknown 28 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2023.
All research outputs
#2,176,872
of 25,032,929 outputs
Outputs from Pediatric Rheumatology
#60
of 794 outputs
Outputs of similar age
#34,748
of 306,493 outputs
Outputs of similar age from Pediatric Rheumatology
#5
of 17 outputs
Altmetric has tracked 25,032,929 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 794 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,493 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.