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Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice

Overview of attention for article published in BMC Gastroenterology, March 2016
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Title
Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice
Published in
BMC Gastroenterology, March 2016
DOI 10.1186/s12876-016-0459-7
Pubmed ID
Authors

Wei Wu, Feng Wang, Xin Gao, Tingting Niu, Xiaojuan Zhu, Xiaojun Yan, Haimin Chen

Abstract

Carrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an "unhealthy" state such as that during bacterial infection or acute inflammation, carrageenan can synergistically enhance the inflammatory response. BALB/C mice received κ-carrageenan via intragastric administration prior to the induction of oxazolone colitis. Weight changes, survival rate, histologic change, secretion of inflammatory cytokines, ratio of regulatory T cells (Tregs) in peripheral blood, and expression of genes and proteins involved in inflammation and cell proliferation in the colonic mucosa were examined. Intragastric administration of κ-carrageenan to BALB/c mice prior to the induction of oxazolone colitis resulted in an aggravation of body weight loss, a decrease in the survival ratio, aggravation of colonic inflammation, and decrease in the ratio of CD4 + CD25+/CD4+. The secretion of interleukin-4 (IL-4), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) also significantly increased after κ-carrageenan administration. κ-Carrageenan, together with oxazolone, suppressed the expression of forkhead box p3 (FOXp3) and increased the expression of Toll-like receptor 4 (TLR4), Nuclear factor-κB (NF-κB), and proliferating cell nuclear antigen in the colonic mucosa. These results were confirmed by qRT-PCR and western blot analyses at the molecular and protein levels, respectively. κ-Carrageenan aggravated oxazolone-induced intestinal inflammation in BALB/c mice. This effect is associated with an activation of the TLR4-NF-κB pathway, a decreased ratio of Tregs, and the induction of Th2-dependent immune responses.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 20%
Researcher 3 20%
Other 2 13%
Student > Ph. D. Student 2 13%
Student > Postgraduate 2 13%
Other 0 0%
Unknown 3 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 40%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Chemistry 1 7%
Medicine and Dentistry 1 7%
Other 0 0%
Unknown 5 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2017.
All research outputs
#9,076,739
of 11,337,680 outputs
Outputs from BMC Gastroenterology
#539
of 754 outputs
Outputs of similar age
#201,655
of 286,466 outputs
Outputs of similar age from BMC Gastroenterology
#9
of 17 outputs
Altmetric has tracked 11,337,680 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 754 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,466 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.