Title |
Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors
|
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Published in |
Journal of Biomedical Science, February 2012
|
DOI | 10.1186/1423-0127-19-14 |
Pubmed ID | |
Authors |
Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren, Zhuo Yang |
Abstract |
Nanomaterials, as a new kind of materials, have been greatly applied in different fields due to their special properties. With the industrialization of nanostructured materials and increasing public exposure, the biosafety and potential influences on central nervous system (CNS) have received more attention. Nanosized zinc oxide (nanoZnO) was suggested to up-regulate neuronal excitability and to induce glutamate release in vitro. Therefore, we hypothesized nanoparticles of nanoZnO may lead to changes in balance of neurotransmitter or neuronal excitability of CNS. This study was to investigate if there were effects of nanoZnO on animal model of depression. |
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