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Advances in using PARP inhibitors to treat cancer

Overview of attention for article published in BMC Medicine, March 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
94 Dimensions

Readers on

mendeley
97 Mendeley
citeulike
1 CiteULike
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Title
Advances in using PARP inhibitors to treat cancer
Published in
BMC Medicine, March 2012
DOI 10.1186/1741-7015-10-25
Pubmed ID
Authors

Shivaani Kummar, Alice Chen, Ralph E Parchment, Robert J Kinders, Jay Ji, Joseph E Tomaszewski, James H Doroshow

Abstract

The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with overall prognosis in cancer, especially breast cancer. A series of new therapeutic agents that are potent inhibitors of the PARP1 and PARP2 isoforms have demonstrated important clinical activity in patients with breast or ovarian cancers that are caused by mutations in either the BRCA1 or 2 genes. Results from such studies may define a new therapeutic paradigm, wherein simultaneous loss of the capacity to repair DNA damage may have antitumor activity in itself, as well as enhance the antineoplastic potential of cytotoxic chemotherapeutic agents.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Netherlands 2 2%
United Kingdom 2 2%
Nigeria 1 1%
India 1 1%
Spain 1 1%
Denmark 1 1%
Unknown 86 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 24%
Researcher 22 23%
Student > Bachelor 15 15%
Student > Master 10 10%
Student > Doctoral Student 5 5%
Other 13 13%
Unknown 9 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 30%
Medicine and Dentistry 21 22%
Biochemistry, Genetics and Molecular Biology 19 20%
Chemistry 7 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 8 8%
Unknown 9 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2015.
All research outputs
#6,738,104
of 12,517,134 outputs
Outputs from BMC Medicine
#1,663
of 2,010 outputs
Outputs of similar age
#52,196
of 116,806 outputs
Outputs of similar age from BMC Medicine
#13
of 18 outputs
Altmetric has tracked 12,517,134 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,010 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,806 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.