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Might dolutegravir be part of a functional cure for HIV?1

Overview of attention for article published in Canadian Journal of Microbiology, January 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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1 X user
facebook
1 Facebook page

Citations

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20 Dimensions

Readers on

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51 Mendeley
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Title
Might dolutegravir be part of a functional cure for HIV?1
Published in
Canadian Journal of Microbiology, January 2016
DOI 10.1139/cjm-2015-0725
Pubmed ID
Authors

Mark A. Wainberg, Ying-Shan Han, Thibault Mesplède

Abstract

Antiretroviral therapy (ART) has greatly decreased HIV-related morbidity and mortality. However, HIV can establish viral reservoirs that evade both the immune system and ART. Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI) related to the first-generation INSTIs raltegravir (RAL) and elvitegravir (EVG). DTG shows a higher genetic barrier to the development of HIV-1 resistance than RAL and EVG. More interestingly, clinical resistance mutations to DTG in treatment-naïve patients have not been observed to date. This review summarizes recent studies on strategies toward a cure for HIV, explores resistance profiles of DTG, and discusses how DTG might help in finding a functional cure for HIV.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Portugal 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 16%
Student > Master 8 16%
Student > Bachelor 7 14%
Other 5 10%
Researcher 4 8%
Other 7 14%
Unknown 12 24%
Readers by discipline Count As %
Medicine and Dentistry 16 31%
Agricultural and Biological Sciences 6 12%
Immunology and Microbiology 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 2 4%
Unknown 16 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2016.
All research outputs
#19,947,956
of 25,377,790 outputs
Outputs from Canadian Journal of Microbiology
#1,724
of 2,141 outputs
Outputs of similar age
#282,939
of 405,751 outputs
Outputs of similar age from Canadian Journal of Microbiology
#11
of 29 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,141 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,751 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.