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Might dolutegravir be part of a functional cure for HIV?

Overview of attention for article published in Canadian Journal of Microbiology, May 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

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10 Dimensions

Readers on

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26 Mendeley
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Title
Might dolutegravir be part of a functional cure for HIV?
Published in
Canadian Journal of Microbiology, May 2016
DOI 10.1139/cjm-2015-0725
Pubmed ID
Authors

Mark A. Wainberg, Ying-Shan Han, Thibault Mesplède

Abstract

Antiretroviral therapy (ART) has greatly decreased HIV-related morbidity and mortality. However, HIV can establish viral reservoirs that evade both the immune system and ART. Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI) related to the first-generation INSTIs raltegravir (RAL) and elvitegravir (EVG). DTG shows a higher genetic barrier to the development of HIV-1 resistance than RAL and EVG. More interestingly, clinical resistance mutations to DTG in treatment-naïve patients have not been observed to date. This review summarizes recent studies on strategies toward a cure for HIV, explores resistance profiles of DTG, and discusses how DTG might help in finding a functional cure for HIV.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Portugal 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 27%
Researcher 4 15%
Other 3 12%
Student > Bachelor 3 12%
Unspecified 3 12%
Other 6 23%
Readers by discipline Count As %
Medicine and Dentistry 9 35%
Unspecified 5 19%
Biochemistry, Genetics and Molecular Biology 4 15%
Agricultural and Biological Sciences 3 12%
Immunology and Microbiology 3 12%
Other 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2016.
All research outputs
#4,363,837
of 9,101,840 outputs
Outputs from Canadian Journal of Microbiology
#404
of 831 outputs
Outputs of similar age
#129,115
of 281,010 outputs
Outputs of similar age from Canadian Journal of Microbiology
#6
of 23 outputs
Altmetric has tracked 9,101,840 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 831 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,010 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.