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Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Overview of attention for article published in Nature Communications, March 2016
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Title
Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
Published in
Nature Communications, March 2016
DOI 10.1038/ncomms11082
Pubmed ID
Authors

Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper

Abstract

To maintain tissue integrity during epithelial morphogenesis, adherens junctions (AJs) must resist the mechanical stresses exerted by dynamic tissue movements. Junctional stability is dependent on actomyosin contractility within the actin ring. Here we describe a novel function for the axon guidance receptor, Neogenin, as a key component of the actin nucleation machinery governing junctional stability. Loss of Neogenin perturbs AJs and attenuates junctional tension. Neogenin promotes actin nucleation at AJs by recruiting the Wave regulatory complex (WRC) and Arp2/3. A direct interaction between the Neogenin WIRS domain and the WRC is crucial for the spatially restricted recruitment of the WRC to the junction. Thus, we provide the first example of a functional WIRS-WRC interaction in epithelia. We further show that Neogenin regulates cadherin recycling at the AJ. In summary, we identify Neogenin as a pivotal component of the AJ, where it influences both cadherin dynamics and junctional tension.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Germany 1 3%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 28%
Student > Master 6 17%
Student > Bachelor 6 17%
Researcher 3 8%
Unspecified 2 6%
Other 9 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 33%
Biochemistry, Genetics and Molecular Biology 11 31%
Neuroscience 4 11%
Unspecified 3 8%
Chemistry 2 6%
Other 4 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
All research outputs
#9,376,867
of 12,220,965 outputs
Outputs from Nature Communications
#17,421
of 19,536 outputs
Outputs of similar age
#183,148
of 281,477 outputs
Outputs of similar age from Nature Communications
#268
of 292 outputs
Altmetric has tracked 12,220,965 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,536 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.1. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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