Title |
Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression
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Published in |
Breast Cancer Research, March 2012
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DOI | 10.1186/bcr3137 |
Pubmed ID | |
Authors |
Mohan Liu, Liewei Wang, Tim Bongartz, John R Hawse, Svetomir N Markovic, Daniel J Schaid, Taisei Mushiroda, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Paul E Goss, James N Ingle, Richard M Weinshilboum |
Abstract |
Arthralgias and myalgias are major side effects associated with aromatase inhibitor (AI) therapy of breast cancer. In a recent genome-wide association study, we identified SNPs - including one that created an estrogen response element near the 3' end of the T-cell leukemia 1A (TCL1A) gene - that were associated with musculoskeletal pain in women on adjuvant AI therapy for breast cancer. We also showed estrogen-dependent, SNP-modulated variation in TCL1A expression and, in preliminary experiments, showed that TCL1A could induce IL-17RA expression. In the present study, we set out to determine whether these SNPs might influence cytokine expression and effect more widely, and, if so, to explore the mechanism of TCL1A-related AI-induced side effects. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 2% |
Germany | 1 | 2% |
Unknown | 46 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 19% |
Researcher | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Student > Master | 5 | 10% |
Other | 4 | 8% |
Other | 9 | 19% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 27% |
Agricultural and Biological Sciences | 8 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
Psychology | 3 | 6% |
Other | 4 | 8% |
Unknown | 10 | 21% |