Chapter 1 A Brief Overview of N -Acetylaspartate and N -Acetylaspartylglutamate

Chapter 2 Expression of N -Acetylaspartate and N -Acetylaspartylglutamate in the Nervous System

Chapter 3 N -Acetylaspartate Metabolism in Neural Cells

Chapter 4 Naa Synthesis and Functional Roles

Chapter 5 Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the N -Acetyl-L-Aspartate Transporter

Chapter 6 Canavan Disease: Studies on the Knockout Mouse

Chapter 7 Functions Of N -Acetylaspartate and N -Acetylaspartylglutamate in Brain

Chapter 8 Control of Brain Volume during Hypoosmolality and Hyperosmolality

Chapter 9 Physiological Role of N -Acetylaspartate

Chapter 10 Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canavan Disease

Chapter 11 Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease

Chapter 12 Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?

Chapter 13 Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy

Chapter 14 N-Acetyl-L-Aspartate in Multiple Sclerosis

Chapter 15 NAA and higher cognitive function in humans.

Chapter 16 In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia

Chapter 17 N -Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease

Chapter 18 Regulation of NAA-Synthesis in the Human Brain in Vivo: Canavan’s Disease, Alzheimer’s Disease and Schizophrenia

Chapter 19 Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis

Chapter 20 Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient

Chapter 21 Cellular localization of NAAG.

Chapter 22 Synthesis of N-acetylaspartyl-glutamate (NAAG) and N-acetylaspartate (NAA) in axons and glia of the crayfish medial giant nerve fiber.

Chapter 23 NAAG as a neurotransmitter.

Chapter 24 Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.

Chapter 26 N-acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher disease.

Chapter 27 Concluding Remarks