Title |
Intestinal mucosal barrier function in health and disease
|
---|---|
Published in |
Nature Reviews Immunology, November 2009
|
DOI | 10.1038/nri2653 |
Pubmed ID | |
Authors |
Jerrold R. Turner |
Abstract |
Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | <1% |
United Kingdom | 8 | <1% |
Japan | 5 | <1% |
Ireland | 4 | <1% |
Germany | 4 | <1% |
Argentina | 3 | <1% |
Netherlands | 3 | <1% |
France | 2 | <1% |
Italy | 2 | <1% |
Other | 15 | <1% |
Unknown | 2136 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 429 | 20% |
Student > Master | 303 | 14% |
Researcher | 287 | 13% |
Student > Bachelor | 246 | 11% |
Student > Doctoral Student | 144 | 7% |
Other | 332 | 15% |
Unknown | 456 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 537 | 24% |
Medicine and Dentistry | 337 | 15% |
Biochemistry, Genetics and Molecular Biology | 286 | 13% |
Immunology and Microbiology | 178 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 73 | 3% |
Other | 265 | 12% |
Unknown | 521 | 24% |