| Title |
Circadian clocks and the regulation of virulence in fungi: Getting up to speed
|
|---|---|
| Published in |
Seminars in Cell & Developmental Biology, March 2016
|
| DOI | 10.1016/j.semcdb.2016.03.021 |
| Pubmed ID | |
| Authors |
Montserrat A. Hevia, Paulo Canessa, Luis F. Larrondo |
| Abstract |
You cannot escape time. Therefore, it seems wise to learn how to keep track of it and use it to your advantage. Circadian clocks are molecular circuits that allow organisms to temporally coordinate a plethora of processes, including gene expression, with a close to 24hours rhythm, optimizing cellular function in synchrony with daily environmental cycles. The molecular bases of these clocks have been extensively studied in the fungus Neurospora crassa, providing a detailed molecular description. Surprisingly, there is scarce molecular information of clocks in fungi other than Neurospora, despite the existence of rhythmic phenomena in many fungal species, including pathogenic ones. This review will comment on the overall importance of clocks, what is known in Neurospora and what has been described in other fungi including new insights on the evolution of fungal clock components. The molecular description of the circadian system of the phytopathogenic fungus Botrytis cinerea will be revisited, as well as time-of-the-day variation in host-pathogen interaction dynamics, utilizing an Arabidopsis-Botrytis system, including also what is known regarding circadian regulation of defense mechanisms in the Arabidopsis thaliana plant model. Finally, this review will mention how little is known about circadian regulation of human pathogenic fungi, commenting on potential future directions and the overall perspective of fungal circadian studies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| France | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 70 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 23% |
| Researcher | 13 | 18% |
| Student > Bachelor | 8 | 11% |
| Student > Master | 8 | 11% |
| Student > Doctoral Student | 6 | 8% |
| Other | 10 | 14% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 47% |
| Biochemistry, Genetics and Molecular Biology | 14 | 19% |
| Chemistry | 3 | 4% |
| Immunology and Microbiology | 2 | 3% |
| Neuroscience | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 12 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2016.
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#20,656,161
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Outputs from Seminars in Cell & Developmental Biology
#1,689
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#234,713
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Outputs of similar age from Seminars in Cell & Developmental Biology
#29
of 37 outputs
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