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Baicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrest

Overview of attention for article published in Cell & Bioscience, April 2016
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Title
Baicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrest
Published in
Cell & Bioscience, April 2016
DOI 10.1186/s13578-016-0084-8
Pubmed ID
Authors

Chunjie Yu, Jiancheng Zeng, Zhenzhen Yan, Zi Ma, Shangqin Liu, Zan Huang

Abstract

The prognosis of acute megakaryoblastic leukemia (AMKL) is really dismal, which urges for development of novel treatment. Baicalein is one type of flavonoids extracted from Scutellaria baicalensis Georgi (Huang Qin). It inhibited cell proliferation and subcutaneous tumor formation of many tumor cell lines. However, whether baicalein possesses anti-AMKL activities has not been tested. We found that baicalein potently inhibited proliferation of multiple AMKL cells including CMK, CMY, Y10, 6133, and 6133 MPL/W515L due to apoptosis and cell cycle arrest at G1 phase. Unexpectedly, caspase inhibitor z-VAD-fmk did not restore cell proliferation. In contrast, ectopic expression of Cyclin D1 efficiently antagonized the inhibitory effect of baicalein. In addition, baicalein induced differentiation of 6133 MPL/W515L cells. Finally, baicalein promoted mice survival and reduced disease burden in a mouse model of AMKL. Baicalein possesses potent anti-AMKL activity in vitro and in vivo. Baicalein may be a potent reagent for AMKL therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 30%
Lecturer 2 20%
Researcher 1 10%
Student > Master 1 10%
Lecturer > Senior Lecturer 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 3 30%
Biochemistry, Genetics and Molecular Biology 3 30%
Agricultural and Biological Sciences 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Unknown 2 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2016.
All research outputs
#5,670,496
of 7,492,829 outputs
Outputs from Cell & Bioscience
#113
of 170 outputs
Outputs of similar age
#191,313
of 272,154 outputs
Outputs of similar age from Cell & Bioscience
#9
of 16 outputs
Altmetric has tracked 7,492,829 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 170 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.