@marc_rr @Omar_MalinGenie Merci pour la précision 🤗 ds le cas du HGP ce fut pourtant un mix ethnique (meme si issus d’un petit nb d’individus). Du coup est-ce utopique de vouloir UN genome de reference ? Voir: https://t.co/AZmaNnt7dB
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Read this paper as a starting point on the topic and I think it's very interesting! I have no strict opinions at the moment, but I definitely want to do more research👀 https://t.co/iEyajZou0p
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I'm still on this topic lol Concluding my reading today with this very lucidly written article. (open-access) https://t.co/yCbAXZSCE1
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@robertbrussell Yes, this is down to the reference genome used. There are several with GRCh38 being commonly used in many places; gnomAD has data with both GRCh37/hg19 and GRCh38. For some background see eg “Is it time to change the reference genome?” htt