@AllenFrancesMD CYP2D6 loss-of-function alleles distributed on a North-to-South gradient, and CYP2D6*4 & CYP2D6*5 have an inverse profile. CYP2D6*4 most prevalent in Northern & Central Europe freq. ~20–25%. High CYP2D6*4 frequency in Europe in the
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@__ice9 CYP2D6 polymorphism affecting metabolism of HCQ in a small % of the population? https://t.co/WwR3cBj7LF
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CYP2D6 polymorphisms in Europe, patterns of distribution and geography. https://t.co/WwR3cBAJaf https://t.co/W4hfUVY6K8
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RT @ejhg_journal: The population frequency of genomic variants which influence drug metabolism vary across different European populations,…