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Efficacy of four commercially available heartworm preventive products against the JYD-34 laboratory strain of Dirofilaria immitis

Overview of attention for article published in Parasites & Vectors, April 2016
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Mentioned by

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1 tweeter
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1 patent

Citations

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20 Dimensions

Readers on

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18 Mendeley
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Title
Efficacy of four commercially available heartworm preventive products against the JYD-34 laboratory strain of Dirofilaria immitis
Published in
Parasites & Vectors, April 2016
DOI 10.1186/s13071-016-1476-7
Pubmed ID
Authors

Byron L. Blagburn, Robert G. Arther, Allen R. Dillon, Jamie M. Butler, Joy V. Bowles, Cristiano von Simson, Robert Zolynas

Abstract

Heartworm disease in dogs can be severe and life threatening. Resistance to available heartworm preventives was considered among potential causes of increased reports of failed heartworm prevention in dogs. The objective of the present study was to compare the efficacy of four commercially available heartworm disease preventives against the JYD-34 strain of D. immitis. Forty laboratory-reared dogs approximately 6 months old were used. Each dog was infected with fifty, third-stage heartworm larvae on study day (SD) -30. On SD-1, the dogs were randomized to five groups of eight dogs each. On SD-0, dogs in groups 1-4 were treated as follows: Group 1: ivermectin/pyrantel pamoate chewable tablets; Group 2: milbemycin oxime/spinosad tablets; Group 3: selamectin topical solution; and Group 4: imidacloprid/moxidectin topical solution. Dogs in Group 5 were not treated and served as controls. The dogs were treated according to their current body weights and labelled dose banding for each product. Groups 1, 2, and 3 were retreated with their respective products and current body weights on SD 31 and 60. On SDs 124-126 the dogs were euthanized and necropsied for recovery of adult heartworms. Adult heartworms were recovered at necropsy from each of the dogs in the control group (13-32 worms/dog, geometric mean (GM) = 18.4 worms/dog). Adult heartworms and/or worm fragments were also recovered from each of the dogs treated with ivermectin/pyrantel pamoate, milbemycin oxime/spinosad or selamectin. Geometric means of worms recovered from dogs in each of these groups were 13.1, 8.8, and 13.1, resulting in efficacies compared to controls of 29.0, 52.2, and 28.8 %, respectively. All dogs in Group 4 (imidacloprid/moxidectin) were free of adult heartworms (100 % efficacy). The combination of imidacloprid/moxidectin was 100 % effective in this study in preventing development of JYD-34 laboratory strain of D. immitis in dogs following a single treatment, while three monthlytreatments of the three other commercial products provided less than 100 % efficacy. The high efficacy achieved with imidacloprid/moxidectin was likely due to the unique pharmacokinetic properties of the topical formulation delivering greater and sustained drug concentrations necessary to prevent development of D. immitis larvae.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 17%
Other 3 17%
Student > Master 3 17%
Researcher 2 11%
Student > Ph. D. Student 2 11%
Other 3 17%
Unknown 2 11%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 33%
Medicine and Dentistry 2 11%
Immunology and Microbiology 2 11%
Business, Management and Accounting 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 4 22%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2016.
All research outputs
#2,316,654
of 9,365,896 outputs
Outputs from Parasites & Vectors
#599
of 2,697 outputs
Outputs of similar age
#85,839
of 280,306 outputs
Outputs of similar age from Parasites & Vectors
#38
of 190 outputs
Altmetric has tracked 9,365,896 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,697 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,306 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 190 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.