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Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, January 2019
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Title
Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon
Published in
Memórias do Instituto Oswaldo Cruz, January 2019
DOI 10.1590/0074-02760190054
Pubmed ID
Authors

Lilian Rose Pratt-Riccio, Bárbara de Oliveira Baptista, Vanessa Rodrigues Torres, Cesare Bianco-Junior, Daiana de Souza Perce-Da-Silva, Evelyn Kety Pratt Riccio, Josué da Costa Lima-Junior, Paulo Renato Rivas Totino, Gustavo Capatti Cassiano, Luciane Moreno Storti-Melo, Ricardo Luiz Dantas Machado, Joseli de Oliveira-Ferreira, Dalma Maria Banic, Leonardo José de Moura Carvalho, Cláudio Tadeu Daniel-Ribeiro

Abstract

The central repetitive region (CRR) of the Plasmodium vivax circumsporozoite surface protein (CSP) is composed of a repetitive sequence that is characterised by three variants: VK210, VK247 and P. vivax-like. The most important challenge in the treatment of P. vivax infection is the possibility of differential response based on the parasite genotype. To characterise the CSP variants in P. vivax isolates from individuals residing in a malaria-endemic region in Brazil and to profile these variants based on sensitivity to chloroquine and mefloquine. The CSP variants were determined by sequencing and the sensitivity of the P. vivax isolates to chloroquine and mefloquine was determined by Deli-test. Although five different allele sizes were amplified, the sequencing results showed that all of the isolates belonged to the VK210 variant. However, we observed substantial genetic diversity in the CRR, resulting in the identification of 10 different VK210 subtypes. The frequency of isolates that were resistant to chloroquine and mefloquine was 11.8 and 23.8%, respectively. However, we did not observe any difference in the frequency of the resistant isolates belonging to the VK210 subtypes. The VK210 variant is the most frequently observed in the studied region and there is significant genetic variability in the CRR of the P. vivax CSP. Moreover, the antimalarial drug sensitivity profiles of the isolates does not seem to be related to the VK210 subtypes.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 32%
Student > Ph. D. Student 3 14%
Student > Postgraduate 2 9%
Unknown 10 45%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 14%
Medicine and Dentistry 2 9%
Immunology and Microbiology 2 9%
Computer Science 1 5%
Unknown 14 64%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2021.
All research outputs
#12,874,806
of 22,418,154 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#788
of 1,360 outputs
Outputs of similar age
#210,378
of 425,347 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#1
of 1 outputs
Altmetric has tracked 22,418,154 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,360 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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