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X Demographics
Mendeley readers
| Title |
Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
|
|---|---|
| Published in |
BMC Biology, March 2012
|
| DOI | 10.1186/1741-7007-10-24 |
| Pubmed ID | |
| Authors |
Dawn M Wenzel, Rachel E Klevit |
| Abstract |
Ubiquitin signaling pathways rely on E3 ligases for effecting the final transfer of ubiquitin from E2 ubiquitin conjugating enzymes to a protein target. Here we re-evaluate the hybrid RING/HECT mechanism used by the E3 family RING-between-RINGs (RBRs) to transfer ubiquitin to substrates. We place RBRs into the context of current knowledge of HECT and RING E3s. Although not as abundant as the other types of E3s (there are only slightly more than a dozen RBR E3s in the human genome), RBRs are conserved in all eukaryotes and play important roles in biology. Re-evaluation of RBR ligases as RING/HECT E3s provokes new questions and challenges the field. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Japan | 1 | <1% |
| Chile | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 105 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 32% |
| Researcher | 14 | 13% |
| Student > Master | 14 | 13% |
| Student > Bachelor | 11 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 41% |
| Biochemistry, Genetics and Molecular Biology | 35 | 32% |
| Chemistry | 4 | 4% |
| Arts and Humanities | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 16 | 15% |