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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Wolbachia surface protein induces innate immune responses in mosquito cells
|
|---|---|
| Published in |
BMC Microbiology, January 2012
|
| DOI | 10.1186/1471-2180-12-s1-s11 |
| Pubmed ID | |
| Authors |
Sofia B Pinto, Mara Mariconti, Chiara Bazzocchi, Claudio Bandi, Steven P Sinkins |
| Abstract |
BACKGROUND: Wolbachia endosymbiotic bacteria are capable of inducing chronic upregulation of insect immune genes in some situations and this phenotype may influence the transmission of important insect-borne pathogens. However the molecules involved in these interactions have not been characterized. RESULTS: Here we show that recombinant Wolbachia Surface Protein (WSP) stimulates increased transcription of immune genes in mosquito cells derived from the mosquito Anopheles gambiae, which is naturally uninfected with Wolbachia; at least two of the upregulated genes, TEP1 and APL1, are known to be important in Plasmodium killing in this species. When cells from Aedes albopictus, which is naturally Wolbachia-infected, were challenged with WSP lower levels of upregulation were observed than for the An. gambiae cells. CONCLUSIONS: We have found that WSP is a strong immune elicitor in a naturally Wolbachia-uninfected mosquito species (Anopheles gambiae) while a milder elicitor in a naturally-infected species (Aedes albopictus). Since the WSP of a mosquito non-native (nematode) Wolbachia strain was used, these data suggest that there is a generalized tolerance to WSP in Ae. albopictus. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 2 | 2% |
| Italy | 1 | <1% |
| Uganda | 1 | <1% |
| Indonesia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 99 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 21% |
| Researcher | 23 | 21% |
| Student > Master | 18 | 17% |
| Student > Bachelor | 8 | 7% |
| Student > Doctoral Student | 6 | 6% |
| Other | 18 | 17% |
| Unknown | 11 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 58% |
| Biochemistry, Genetics and Molecular Biology | 13 | 12% |
| Medicine and Dentistry | 5 | 5% |
| Environmental Science | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 10 | 9% |
| Unknown | 10 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2012.
All research outputs
#20,156,138
of 22,663,969 outputs
Outputs from BMC Microbiology
#2,666
of 3,162 outputs
Outputs of similar age
#222,509
of 245,909 outputs
Outputs of similar age from BMC Microbiology
#68
of 72 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,162 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,909 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.