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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
The success of microneedle-mediated vaccine delivery into skin
|
|---|---|
| Published in |
Human vaccines immunotherapeutics, April 2016
|
| DOI | 10.1080/21645515.2016.1171440 |
| Pubmed ID | |
| Authors |
Sarah Marshall, Laura J. Sahm, Anne C. Moore |
| Abstract |
Microneedles (MNs) are designed to specifically target the outermost, skin barrier layer, the stratum corneum, creating transient pathways for minimally invasive transcutaneous delivery. It is reported that MNs can facilitate delivery without stimulating the pain receptors or damaging blood vessels that lie beneath, thus being perceived as painless and associated with reduced bleeding. This immunocompetence of the skin, coupled with its ease of access, makes this organ an attractive vaccination site. The purpose of this review was to collate primary scientific literature pertaining to MN-mediated in vivo vaccination programmes. A total of 62 original research articles are presented, compiling vaccination strategies in 6 different models (mouse, rat, guinea pig, rabbit, pig, macaque and human). Vaccines tested span a wide range of viral, bacterial and protozoan pathogens and includes 7 of the 13 vaccine-preventable diseases, as defined by the WHO. This review highlights the paucity of available clinical trial data. MN-delivered vaccines have demonstrated safety and immunogenicity in pre-clinical models and boast desirable attributes such as painless administration, thermostability, dose-sparing capacity and the potential for self-administration. These advantages should contribute to enhanced global vaccine access. |
Twitter Demographics
The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 152 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 18% |
| Student > Ph. D. Student | 23 | 15% |
| Student > Bachelor | 22 | 14% |
| Researcher | 16 | 10% |
| Student > Doctoral Student | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 39 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 35 | 23% |
| Biochemistry, Genetics and Molecular Biology | 15 | 10% |
| Medicine and Dentistry | 12 | 8% |
| Engineering | 10 | 7% |
| Agricultural and Biological Sciences | 5 | 3% |
| Other | 30 | 20% |
| Unknown | 46 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#3,572,082
of 22,764,165 outputs
Outputs from Human vaccines immunotherapeutics
#667
of 3,171 outputs
Outputs of similar age
#57,626
of 300,964 outputs
Outputs of similar age from Human vaccines immunotherapeutics
#18
of 81 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,171 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,964 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.