↓ Skip to main content

Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2

Overview of attention for article published in Journal of Enzyme Inhibition & Medicinal Chemistry, March 2012
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
6 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
Published in
Journal of Enzyme Inhibition & Medicinal Chemistry, March 2012
DOI 10.3109/14756366.2012.666539
Pubmed ID
Authors

Maja Radisavljević, Tina Kamčeva, Živadin D. Bugarčić, Marijana Petković

Abstract

This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH₃)₂Cl₂, and [Pt(dach)Cl₂] on the activity of porcine pancreatic phospholipase A₂ (PLA₂). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl₂] with PLA₂ could not be detected under our experimental conditions.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 33%
Student > Postgraduate 1 17%
Researcher 1 17%
Student > Master 1 17%
Unknown 1 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 33%
Nursing and Health Professions 1 17%
Chemistry 1 17%
Engineering 1 17%
Unknown 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2012.
All research outputs
#2,899,952
of 3,630,009 outputs
Outputs from Journal of Enzyme Inhibition & Medicinal Chemistry
#79
of 422 outputs
Outputs of similar age
#57,467
of 80,279 outputs
Outputs of similar age from Journal of Enzyme Inhibition & Medicinal Chemistry
#4
of 38 outputs
Altmetric has tracked 3,630,009 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 422 research outputs from this source. They receive a mean Attention Score of 0.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 80,279 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.