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Grape seed protects cholestatic rats liver from ischemia/reperfusion injury

Overview of attention for article published in Acta Cirurgica Brasileira, March 2016
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Title
Grape seed protects cholestatic rats liver from ischemia/reperfusion injury
Published in
Acta Cirurgica Brasileira, March 2016
DOI 10.1590/s0102-865020160030000006
Pubmed ID
Authors

Tuğrul Çakır, Arif Aslaner, Seçkin Özgür Tekeli, Kasım Güneş, Erdem Kinaci, Uğur Doğan, Feyza Tekeli, Cebrail Akyüz, Süleyman Koç, Necat Yılmaz

Abstract

To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/day grape-seed extract was started 15 days before bile duct ligation and continued to the second operation in the study group. Serum, plasma and liver samples were taken. Laboratory analysis, tissue gluthation, malondialdehyde, myeloperoxidase levels and histopathological examination were performed. Significant decrease in liver gluthation level and significant increase in malondialdehyde level and myeloperoxidase activity were observed after ischemia/reperfusion in cholestatic rats. Serum and plasma levels for laboratory analysis were also significantly higher in cholestatic I/R group. Hepatic necrosis and fibrosis were detected in histopathological examination. Oral grape-seed extract administiration reversed all these parameters and histopathological findings except serum bilirubin levels. Oral grape-seed extract treatment can improve liver functions and attenuate the inflammation and oxidative stress in cholestatic ischemia/reperfusion injury.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 20%
Student > Master 1 10%
Student > Ph. D. Student 1 10%
Student > Doctoral Student 1 10%
Professor > Associate Professor 1 10%
Other 0 0%
Unknown 4 40%
Readers by discipline Count As %
Medicine and Dentistry 5 50%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Unknown 4 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2016.
All research outputs
#11,999,273
of 13,530,814 outputs
Outputs from Acta Cirurgica Brasileira
#104
of 145 outputs
Outputs of similar age
#219,674
of 262,257 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#2
of 5 outputs
Altmetric has tracked 13,530,814 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 145 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,257 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.