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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes
|
|---|---|
| Published in |
ACS Infectious Diseases, April 2016
|
| DOI | 10.1021/acsinfecdis.6b00025 |
| Pubmed ID | |
| Authors |
Pamela A. Magistrado, Victoria C. Corey, Amanda K. Lukens, Greg LaMonte, Erika Sasaki, Stephan Meister, Melanie Wree, Elizabeth Winzeler, Dyann F. Wirth |
| Abstract |
MMV007564 is a novel antimalarial benzimidazolyl piperidine chemotype identified in cellular screens. To identify the genetic determinant of MMV007564 resistance, parasites were cultured in the presence of the compound to generate resistant lines. Whole genome sequencing revealed distinct mutations in the gene named Plasmodium falciparum cyclic amine resistance locus (pfcarl), encoding a conserved protein of unknown function. Mutations in pfcarl are strongly associated with resistance to a structurally unrelated class of compounds, the imidazolopiperazines, including KAF156, currently in clinical trials. Our data demonstrate that pfcarl mutations confer resistance to two distinct compound classes, benzimidazolyl piperidines and imidazolopiperazines. However, MMV007564 and the imidazolopiperazines, KAF156 and GNF179, have different timings of action in the asexual blood stage and different potencies against the liver and sexual blood stages. These data suggest that pfcarl is a multidrug-resistance gene rather than a common target for benzimidazolyl piperidines and imidazolopiperazines. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 23% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Master | 8 | 13% |
| Professor > Associate Professor | 3 | 5% |
| Student > Bachelor | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 18 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 16 | 26% |
| Agricultural and Biological Sciences | 6 | 10% |
| Immunology and Microbiology | 6 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Other | 5 | 8% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2016.
All research outputs
#20,657,128
of 25,377,790 outputs
Outputs from ACS Infectious Diseases
#1,246
of 1,507 outputs
Outputs of similar age
#235,281
of 315,515 outputs
Outputs of similar age from ACS Infectious Diseases
#17
of 20 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,507 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,515 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.