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Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

Overview of attention for article published in Acta Neuropathologica Communications, April 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet

Citations

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6 Dimensions

Readers on

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21 Mendeley
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Title
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration
Published in
Acta Neuropathologica Communications, April 2016
DOI 10.1186/s40478-016-0304-9
Pubmed ID
Authors

Ito Kawakami, Zen Kobayashi, Tetsuaki Arai, Osamu Yokota, Takashi Nonaka, Naoya Aoki, Kazuhiro Niizato, Kenichi Oshima, Shinji Higashi, Omi Katsuse, Masato Hosokawa, Masato Hasegawa, Haruhiko Akiyama

Abstract

Choreoathetoid involuntary movements are rarely reported in patients with frontotemporal lobar degeneration (FTLD), suggesting their exclusion as a supportive feature in clinical diagnostic criteria for FTLD. Here, we identified three cases of the behavioral variant of frontotemporal dementia (bvFTD) that display chorea with fused in sarcoma (FUS)-positive inclusions (FTLD-FUS) and the basophilic inclusion body disease (BIBD) subtype. We determined the behavioral and cognitive features in this group that were distinct from other FTLD-FUS cases. We also reviewed the clinical records of 72 FTLD cases, and clarified additional clinical features that are predictive of the BIBD pathology. Symptom onset in the three patients with chorea was at 44.0 years of age (±12.0 years), and occurred in the absence of a family history of dementia. The cases were consistent with a clinical form of FTD known as bvFTD, as well as reduced neurological muscle tone in addition to chorea. The three patients showed no or mild parkinsonism, which by contrast, increased substantially in the other FTLD cases until a later stage of disease. The three patients exhibited severe caudate atrophy, which has previously been reported as a histological feature distinguishing FTLD-FUS from FTLD-tau or FTLD-TAR DNA-binding protein 43. Thus, our findings suggest that the clinical feature of choreoathetosis in bvFTD might be associated with FTLD-FUS, and in particular, with the BIBD subtype.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Philippines 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Other 4 19%
Student > Ph. D. Student 3 14%
Student > Doctoral Student 3 14%
Researcher 3 14%
Student > Postgraduate 2 10%
Other 3 14%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 8 38%
Neuroscience 2 10%
Psychology 2 10%
Decision Sciences 1 5%
Social Sciences 1 5%
Other 3 14%
Unknown 4 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2016.
All research outputs
#1,027,026
of 7,520,778 outputs
Outputs from Acta Neuropathologica Communications
#126
of 352 outputs
Outputs of similar age
#54,953
of 270,904 outputs
Outputs of similar age from Acta Neuropathologica Communications
#17
of 34 outputs
Altmetric has tracked 7,520,778 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 352 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,904 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.