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Immunoexpression of HIF-1α and VEGF in Periodontal Disease and Healthy Gingival Tissues

Overview of attention for article published in Brazilian Dental Journal, April 2016
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Title
Immunoexpression of HIF-1α and VEGF in Periodontal Disease and Healthy Gingival Tissues
Published in
Brazilian Dental Journal, April 2016
DOI 10.1590/0103-6440201600533
Pubmed ID
Authors

Roseane Carvalho Vasconcelos, Antônio de Lisboa Lopes Costa, Roseana de Almeida Freitas, Bruna Aguiar do Amaral Bezerra, Bruna Rafaela Martins dos Santos, Leão Pereira Pinto, Bruno César de Vasconcelos Gurgel

Abstract

Hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) are proteins that stimulate the proliferation and migration of endothelial cells. These proteins have been described in many pathologic and inflammatory conditions, but their involvement in the development of periodontitis has not been thoroughly investigated. This study compared the immunohistochemical expression of these proteins, involved in angiogenesis and hypoxia, by imunnostained inflammatory and endothelial cells in periodontal disease and healthy gingival tissues. Gingival tissue samples were divided as follows: 30 samples with chronic periodontitis, 30 with chronic gingivitis, and 30 of healthy gingiva. Results were analyzed statistically by the Kruskal-Wallis, Mann-Whitney and Spearman correlation tests (p=0.01). Inflammatory and endothelial cells were found to express these proteins. Periodontitis showed median percentage of HIF-1α-positive cells of 39.6%, 22.0% in cases of gingivitis and 0.9% in the healthy gingiva group (p=0.001). For VEGF, median percentage of immunopositive cells was 68.7% for periodontitis, 66.1% in cases for gingivitis, and 19.2% for healthy gingival specimens (p<0.001). Significant correlation between VEGF and HIF-1α was also observed in healthy gingiva (p<0.001).The increased expression of HIF-1αα and VEGF in periodontitis, compared to gingivitis and healthy gingiva, suggests possible activation of the HIF-1α pathway in advanced periodontal disease. The correlation between HIF-1α and VEGF expression in healthy gingiva suggests a physiological function for these proteins in conditions of homeostasis. In periodontal disease, HIF-1 and VEGF expression may be regulated by other factors, in addition to hypoxia, such as bacterial endotoxins and inflammatory cytokines.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Student > Postgraduate 4 14%
Student > Master 3 11%
Student > Bachelor 2 7%
Researcher 2 7%
Other 5 18%
Unknown 8 29%
Readers by discipline Count As %
Medicine and Dentistry 12 43%
Agricultural and Biological Sciences 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Immunology and Microbiology 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 10 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2016.
All research outputs
#10,724,708
of 13,479,390 outputs
Outputs from Brazilian Dental Journal
#61
of 110 outputs
Outputs of similar age
#185,496
of 265,622 outputs
Outputs of similar age from Brazilian Dental Journal
#1
of 1 outputs
Altmetric has tracked 13,479,390 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 110 research outputs from this source. They receive a mean Attention Score of 1.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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