Report for: Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice

Title	Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice
Published in	PLOS ONE, March 2012
DOI	10.1371/journal.pone.0033693
Pubmed ID	22470460
Authors	Shankar Sadasivan, Brooks B. Pond, Amar K. Pani, Chunxu Qu, Yun Jiao, Richard J. Smeyne
Abstract	Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for the symptomatic treatment of ADHD and narcolepsy; although lately, there has been an increased incidence of its use in individuals not meeting the criteria for these disorders. MPH has also been misused as a "cognitive enhancer" and as an alternative to other psychostimulants. Here, we investigate whether chronic or acute administration of MPH in mice at either 1 mg/kg or 10 mg/kg, affects cell number and gene expression in the basal ganglia.

View on publisher site Alert me about new mentions

Twitter Demographics

The data shown below were collected from the profiles of 70 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	16	23%
United Kingdom	4	6%
Comoros	2	3%
Canada	2	3%
France	1	1%
Australia	1	1%
Yemen	1	1%
Mexico	1	1%
Switzerland	1	1%
Other	3	4%
Unknown	38	54%

Demographic breakdown

Type	Count	As %
Members of the public	65	93%
Practitioners (doctors, other healthcare professionals)	3	4%
Scientists	1	1%
Science communicators (journalists, bloggers, editors)	1	1%

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	1	1%
Brazil	1	1%
Unknown	76	97%

Demographic breakdown

Readers by professional status	Count	As %
Student > Bachelor	19	24%
Researcher	17	22%
Student > Ph. D. Student	12	15%
Student > Doctoral Student	7	9%
Other	6	8%
Other	13	17%
Unknown	4	5%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	15	19%
Psychology	14	18%
Medicine and Dentistry	8	10%
Neuroscience	8	10%
Biochemistry, Genetics and Molecular Biology	7	9%
Other	17	22%
Unknown	9	12%

Attention Score in Context

This research output has an Altmetric Attention Score of 106. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2021.

All research outputs

#237,632

of 17,822,916 outputs

Outputs from PLOS ONE

#3,957

of 166,969 outputs

Outputs of similar age

#1,166

of 133,524 outputs

Outputs of similar age from PLOS ONE

#49

of 3,073 outputs

Altmetric has tracked 17,822,916 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 166,969 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one has done particularly well, scoring higher than 97% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,524 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.

We're also able to compare this research output to 3,073 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.

Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice

About this Attention Score

Mentioned by

Citations

Readers on

Twitter Demographics

Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context