Title |
Central Nervous System Mast Cells in Peripheral Inflammatory Nociception
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Published in |
Molecular Pain, January 2011
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DOI | 10.1186/1744-8069-7-42 |
Pubmed ID | |
Authors |
Dimitris N Xanthos, Simon Gaderer, Ruth Drdla, Erin Nuro, Anastasia Abramova, Wilfried Ellmeier, Jürgen Sandkühler |
Abstract |
Functional aspects of mast cell-neuronal interactions remain poorly understood. Mast cell activation and degranulation can result in the release of powerful pro-inflammatory mediators such as histamine and cytokines. Cerebral dural mast cells have been proposed to modulate meningeal nociceptor activity and be involved in migraine pathophysiology. Little is known about the functional role of spinal cord dural mast cells. In this study, we examine their potential involvement in nociception and synaptic plasticity in superficial spinal dorsal horn. Changes of lower spinal cord dura mast cells and their contribution to hyperalgesia are examined in animal models of peripheral neurogenic and non-neurogenic inflammation. |
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Mendeley readers
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