Title |
Further evidence for the existence of major susceptibility of nasopharyngeal carcinoma in the region near HLA-A locus in Southern Chinese
|
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Published in |
Journal of Translational Medicine, March 2012
|
DOI | 10.1186/1479-5876-10-57 |
Pubmed ID | |
Authors |
Manli Zhao, Hongbing Cai, Xin Li, Hang Zheng, Xuexi Yang, Weiyi Fang, Longcheng Zhang, Ganguan Wei, Ming Li, Kaitai Yao, Xin Li |
Abstract |
Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and Epstein-Barr virus infection. Human leukocyte antigen (HLA) complex, specially the region near HLA-A locus, was regarded as a major candidate region bearing NPC genetic susceptibility loci in many previous studies including two recent genome-wide association (GWA) studies. To provide further evidence for the NPC susceptibility in the region near HLA-A locus based on other previous studies, we carried out a two-stage hospital-based case control association study including 535 sporadic NPC patients and 525 cancer-free control subjects from Guangdong, a high prevalence area of NPC in China. |
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