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Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

Overview of attention for article published in Journal of Neuroinflammation, March 2012
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Title
Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection
Published in
Journal of Neuroinflammation, March 2012
DOI 10.1186/1742-2094-9-58
Pubmed ID
Authors

Yael Friedman-Levi, Romana Hoftberger, Herbert Budka, Tehila Mayer-Sonnenfeld, Oded Abramsky, Haim Ovadia, Ruth Gabizon

Abstract

Prions, composed of a misfolded protein designated PrP(Sc), are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomyelitis, prion-infected mice succumb to disease significantly earlier than controls, concomitant with the deposition of PrP(Sc) aggregates in inflamed white matter areas. In the present work, we asked whether prion disease acceleration by experimental autoimmune encephalomyelitis results from infiltration of viable prion-infected immune cells into the central nervous system.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
India 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 27%
Professor 4 13%
Researcher 4 13%
Student > Master 3 10%
Student > Bachelor 2 7%
Other 6 20%
Unknown 3 10%
Readers by discipline Count As %
Medicine and Dentistry 11 37%
Agricultural and Biological Sciences 5 17%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 2 7%
Nursing and Health Professions 1 3%
Other 5 17%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2012.
All research outputs
#18,305,470
of 22,663,969 outputs
Outputs from Journal of Neuroinflammation
#2,045
of 2,604 outputs
Outputs of similar age
#124,189
of 160,638 outputs
Outputs of similar age from Journal of Neuroinflammation
#27
of 36 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,638 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.