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Daily magnesium fluxes regulate cellular timekeeping and energy balance

Overview of attention for article published in Nature, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

38 news outlets
4 blogs
90 tweeters
10 Facebook pages
1 Wikipedia page


66 Dimensions

Readers on

184 Mendeley
Daily magnesium fluxes regulate cellular timekeeping and energy balance
Published in
Nature, April 2016
DOI 10.1038/nature17407
Pubmed ID

Kevin A. Feeney, Louise L. Hansen, Marrit Putker, Consuelo Olivares-Yañez, Jason Day, Lorna J. Eades, Luis F. Larrondo, Nathaniel P. Hoyle, John S. O’Neill, Gerben van Ooijen


Circadian clocks are fundamental to the biology of most eukaryotes, coordinating behaviour and physiology to resonate with the environmental cycle of day and night through complex networks of clock-controlled genes. A fundamental knowledge gap exists, however, between circadian gene expression cycles and the biochemical mechanisms that ultimately facilitate circadian regulation of cell biology. Here we report circadian rhythms in the intracellular concentration of magnesium ions, [Mg(2+)]i, which act as a cell-autonomous timekeeping component to determine key clock properties both in a human cell line and in a unicellular alga that diverged from each other more than 1 billion years ago. Given the essential role of Mg(2+) as a cofactor for ATP, a functional consequence of [Mg(2+)]i oscillations is dynamic regulation of cellular energy expenditure over the daily cycle. Mechanistically, we find that these rhythms provide bilateral feedback linking rhythmic metabolism to clock-controlled gene expression. The global regulation of nucleotide triphosphate turnover by intracellular Mg(2+) availability has potential to impact upon many of the cell's more than 600 MgATP-dependent enzymes and every cellular system where MgNTP hydrolysis becomes rate limiting. Indeed, we find that circadian control of translation by mTOR is regulated through [Mg(2+)]i oscillations. It will now be important to identify which additional biological processes are subject to this form of regulation in tissues of multicellular organisms such as plants and humans, in the context of health and disease.

Twitter Demographics

The data shown below were collected from the profiles of 90 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
Germany 1 <1%
Israel 1 <1%
Portugal 1 <1%
China 1 <1%
Japan 1 <1%
United States 1 <1%
Sweden 1 <1%
Unknown 175 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 24%
Researcher 31 17%
Student > Master 19 10%
Student > Bachelor 18 10%
Other 16 9%
Other 55 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 64 35%
Biochemistry, Genetics and Molecular Biology 56 30%
Unspecified 15 8%
Medicine and Dentistry 12 7%
Neuroscience 12 7%
Other 25 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 361. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2019.
All research outputs
of 13,103,318 outputs
Outputs from Nature
of 68,641 outputs
Outputs of similar age
of 264,659 outputs
Outputs of similar age from Nature
of 1,002 outputs
Altmetric has tracked 13,103,318 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 68,641 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,659 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,002 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.