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IMMUNODIAGNOSIS OF HUMAN STRONGYLOIDIASIS: USE OF SIX DIFFERENT ANTIGENIC FRACTIONS FROM Strongyloides venezuelensis PARASITIC FEMALES

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, October 2015
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Title
IMMUNODIAGNOSIS OF HUMAN STRONGYLOIDIASIS: USE OF SIX DIFFERENT ANTIGENIC FRACTIONS FROM Strongyloides venezuelensis PARASITIC FEMALES
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, October 2015
DOI 10.1590/s0036-46652015000500010
Pubmed ID
Authors

Marcelo Andreetta CORRAL, Fabiana Martins de PAULA, Maiara GOTTARDI, Dirce Mary Correia Lima MEISEL, Vera Lucia Pagliusi CASTILHO, Elenice Messias do Nascimento GONÇALVES, Pedro Paulo CHIEFFI, Ronaldo Cesar Borges GRYSCHEK

Abstract

The aim of this study was to evaluate six different antigenic fractions from Strongyloides venezuelensis parasitic females for the immunodiagnosis of human strongyloidiasis. Soluble and membrane fractions from S. venezuelensis parasitic females were prepared in phosphate-buffered saline (SSF and SMF, respectively), Tris-HCl (TSF and TMF, respectively), and an alkaline buffer (ASF and AMF, respectively). Serum samples obtained from patients with strongyloidiasis or, other parasitic diseases, and healthy individuals were analyzed by enzyme-linked immunosorbent assay (ELISA). Soluble fractions SSF, TSF, and ASF showed 85.0%, 75.0%, and 80.0% sensitivity and 93.1%, 93.1%, and 87.5% specificity, respectively. Membrane fractions SMF, TMF, and AMF showed 80.0%, 75.0%, and 85.0% sensitivity, and 95.8%, 90.3%, and 91.7% specificity, respectively. In conclusion, the present results suggest that the fractions obtained from parasitic females, especially the SSF and SMF, could be used as alternative antigen sources in the serodiagnosis of human strongyloidiasis.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 14%
Unknown 6 86%
Readers by discipline Count As %
Unknown 7 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2016.
All research outputs
#19,218,336
of 21,592,309 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#505
of 622 outputs
Outputs of similar age
#236,586
of 280,580 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#6
of 7 outputs
Altmetric has tracked 21,592,309 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 622 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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