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Mendeley readers
Attention Score in Context
| Title |
Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses
|
|---|---|
| Published in |
Particle and Fibre Toxicology, January 2014
|
| DOI | 10.1186/1743-8977-11-6 |
| Pubmed ID | |
| Authors |
Katelyn J Siegrist, Steven H Reynolds, Michael L Kashon, David T Lowry, Chenbo Dong, Ann F Hubbs, Shih-Houng Young, Jeffrey L Salisbury, Dale W Porter, Stanley A Benkovic, Michael McCawley, Michael J Keane, John T Mastovich, Kristin L Bunker, Lorenzo G Cena, Mark C Sparrow, Jacqueline L Sturgeon, Cerasela Zoica Dinu, Linda M Sargent |
| Abstract |
Carbon nanotubes are commercially-important products of nanotechnology; however, their low density and small size makes carbon nanotube respiratory exposures likely during their production or processing. We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to single-walled carbon nanotubes (SWCNT). In this study, we examined whether multi-walled carbon nanotubes (MWCNT) cause mitotic spindle damage in cultured cells at doses equivalent to 34 years of exposure at the NIOSH Recommended Exposure Limit (REL). MWCNT induced a dose responsive increase in disrupted centrosomes, abnormal mitotic spindles and aneuploid chromosome number 24 hours after exposure to 0.024, 0.24, 2.4 and 24 μg/cm² MWCNT. Monopolar mitotic spindles comprised 95% of disrupted mitoses. Three-dimensional reconstructions of 0.1 μm optical sections showed carbon nanotubes integrated with microtubules, DNA and within the centrosome structure. Cell cycle analysis demonstrated a greater number of cells in S-phase and fewer cells in the G2 phase in MWCNT-treated compared to diluent control, indicating a G1/S block in the cell cycle. The monopolar phenotype of the disrupted mitotic spindles and the G1/S block in the cell cycle is in sharp contrast to the multi-polar spindle and G2 block in the cell cycle previously observed following exposure to SWCNT. One month following exposure to MWCNT there was a dramatic increase in both size and number of colonies compared to diluent control cultures, indicating a potential to pass the genetic damage to daughter cells. Our results demonstrate significant disruption of the mitotic spindle by MWCNT at occupationally relevant exposure levels. |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Poland | 1 | 1% |
| Norway | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 71 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 17% |
| Student > Ph. D. Student | 13 | 17% |
| Student > Master | 12 | 16% |
| Student > Doctoral Student | 8 | 11% |
| Professor | 5 | 7% |
| Other | 14 | 19% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 23% |
| Engineering | 8 | 11% |
| Environmental Science | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Chemistry | 5 | 7% |
| Other | 14 | 19% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2015.
All research outputs
#8,882,501
of 26,017,215 outputs
Outputs from Particle and Fibre Toxicology
#314
of 629 outputs
Outputs of similar age
#102,355
of 329,094 outputs
Outputs of similar age from Particle and Fibre Toxicology
#7
of 11 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 629 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.