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Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

Overview of attention for article published in Cell Communication and Signaling, January 2015
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About this Attention Score

  • Among the highest-scoring outputs from this source (#36 of 171)
  • Good Attention Score compared to outputs of the same age (65th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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12 Dimensions

Readers on

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21 Mendeley
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Title
Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy
Published in
Cell Communication and Signaling, January 2015
DOI 10.1186/s12964-015-0094-x
Pubmed ID
Authors

Yuan Sin, Tamara P Martin, Lauren Wills, Susan Currie, George S Baillie

Abstract

Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the molecular events that govern this event. We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective. This study aims to characterize the role of the complex in PKD1-mediated myocardial regulatory mechanisms that depend on PKD1 nuclear translocation. In mapping the Hsp20 binding sites on PKD1 within its catalytic unit using peptide array analysis, we were able to develop a cell-permeable peptide that disrupts the Hsp20-PKD1 complex. We use this peptide to show that formation of the Hsp20-PKD1 complex is essential for PKD1 nuclear translocation, signaling mechanisms leading to hypertrophy, activation of the fetal gene programme and pathological cardiac remodeling leading to cardiac fibrosis. These results identify a new signaling complex that is pivotal to pathological remodelling of the heart that could be targeted therapeutically.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 33%
Researcher 4 19%
Student > Postgraduate 3 14%
Student > Bachelor 2 10%
Professor 1 5%
Other 3 14%
Unknown 1 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 29%
Agricultural and Biological Sciences 5 24%
Environmental Science 2 10%
Neuroscience 2 10%
Medicine and Dentistry 2 10%
Other 1 5%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2016.
All research outputs
#2,312,820
of 8,800,428 outputs
Outputs from Cell Communication and Signaling
#36
of 171 outputs
Outputs of similar age
#91,254
of 276,939 outputs
Outputs of similar age from Cell Communication and Signaling
#1
of 4 outputs
Altmetric has tracked 8,800,428 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 171 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,939 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them