| Chapter title |
Carbohydrate Microarrays
|
|---|---|
| Chapter number | 16 |
| Book title |
Carbohydrate Microarrays
|
| Published in |
Methods in molecular biology, January 2012
|
| DOI | 10.1007/978-1-61779-373-8_16 |
| Pubmed ID | |
| Book ISBNs |
978-1-61779-372-1, 978-1-61779-373-8
|
| Authors |
Julien Dheur, Nabil Dendane, Rémi Desmet, Fatima Dahmani, Gauthier Goormachtigh, Jérome Vicogne, Véronique Fafeur, Oleg Melnyk, Dheur, Julien, Dendane, Nabil, Desmet, Rémi, Dahmani, Fatima, Goormachtigh, Gauthier, Vicogne, Jérome, Fafeur, Véronique, Melnyk, Oleg |
| Abstract |
The interaction of polysaccharides with proteins modulates or triggers many biological effects. In particular, heparan sulphate proteoglycans (HSPGs) have multiple regulatory interactions with growth factors, enzymes, enzyme inhibitors, and some components of the extracellular matrix. The important role played by HSPGs has motivated the synthesis and selection of HSPG mimetics for modulating the biological activity of HS-binding proteins. We present hereinafter an efficient polysaccharide microarray method that allows the screening of HS-mimetic libraries towards HS-binding growth factors, a major class of polypeptides whose inhibition or potentiation is of high medical interest. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 30% |
| Student > Ph. D. Student | 1 | 10% |
| Other | 1 | 10% |
| Student > Master | 1 | 10% |
| Unknown | 4 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 4 | 40% |
| Agricultural and Biological Sciences | 2 | 20% |
| Medicine and Dentistry | 1 | 10% |
| Unknown | 3 | 30% |