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Impact of HIV on mortality among patients treated for tuberculosis in Lima, Peru: a prospective cohort study

Overview of attention for article published in BMC Infectious Diseases, February 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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1 policy source

Citations

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3 Dimensions

Readers on

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65 Mendeley
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Title
Impact of HIV on mortality among patients treated for tuberculosis in Lima, Peru: a prospective cohort study
Published in
BMC Infectious Diseases, February 2016
DOI 10.1186/s12879-016-1375-8
Pubmed ID
Authors

Gustavo E. Velásquez, J. Peter Cegielski, Megan B. Murray, Martin J. A. Yagui, Luis L. Asencios, Jaime N. Bayona, César A. Bonilla, Hector O. Jave, Gloria Yale, Carmen Z. Suárez, Eduardo Sanchez, Christian Rojas, Sidney S. Atwood, Carmen C. Contreras, Janeth Santa Cruz, Sonya S. Shin

Abstract

Human immunodeficiency virus (HIV)-associated tuberculosis deaths have decreased worldwide over the past decade. We sought to evaluate the effect of HIV status on tuberculosis mortality among patients undergoing treatment for tuberculosis in Lima, Peru, a low HIV prevalence setting. We conducted a prospective cohort study of patients treated for tuberculosis between 2005 and 2008 in two adjacent health regions in Lima, Peru (Lima Ciudad and Lima Este). We constructed a multivariate Cox proportional hazards model to evaluate the effect of HIV status on mortality during tuberculosis treatment. Of 1701 participants treated for tuberculosis, 136 (8.0 %) died during tuberculosis treatment. HIV-positive patients constituted 11.0 % of the cohort and contributed to 34.6 % of all deaths. HIV-positive patients were significantly more likely to die (25.1 vs. 5.9 %, P < 0.001) and less likely to be cured (28.3 vs. 39.4 %, P = 0.003). On multivariate analysis, positive HIV status (hazard ratio [HR] = 6.06; 95 % confidence interval [CI], 3.96-9.27), unemployment (HR = 2.24; 95 % CI, 1.55-3.25), and sputum acid-fast bacilli smear positivity (HR = 1.91; 95 % CI, 1.10-3.31) were significantly associated with a higher hazard of death. We demonstrate that positive HIV status was a strong predictor of mortality among patients treated for tuberculosis in the early years after Peru started providing free antiretroviral therapy. As HIV diagnosis and antiretroviral therapy provision are more widely implemented for tuberculosis patients in Peru, future operational research should document the changing profile of HIV-associated tuberculosis mortality.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Malawi 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Researcher 11 17%
Other 5 8%
Student > Ph. D. Student 5 8%
Student > Bachelor 5 8%
Other 16 25%
Unknown 10 15%
Readers by discipline Count As %
Medicine and Dentistry 23 35%
Nursing and Health Professions 7 11%
Biochemistry, Genetics and Molecular Biology 5 8%
Immunology and Microbiology 5 8%
Agricultural and Biological Sciences 4 6%
Other 7 11%
Unknown 14 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2017.
All research outputs
#2,323,492
of 8,838,295 outputs
Outputs from BMC Infectious Diseases
#1,046
of 3,911 outputs
Outputs of similar age
#91,270
of 277,013 outputs
Outputs of similar age from BMC Infectious Diseases
#36
of 111 outputs
Altmetric has tracked 8,838,295 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 3,911 research outputs from this source. They receive a mean Attention Score of 4.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,013 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.