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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children
|
|---|---|
| Published in |
Malaria Journal, April 2016
|
| DOI | 10.1186/s12936-016-1266-x |
| Pubmed ID | |
| Authors |
Michael J. Boivin, Alla Sikorskii, Itziar Familiar-Lopez, Horacio Ruiseñor-Escudero, Mary Muhindo, James Kapisi, Victor Bigira, Judy K. Bass, Robert O. Opoka, Noeline Nakasujja, Moses Kamya, Grant Dorsey |
| Abstract |
Asymptomatic falciparum malaria is associated with poorer cognitive performance in African schoolchildren and intermittent preventive treatment of malaria improves cognitive outcomes. However, the developmental benefits of chemoprevention in early childhood are unknown. Early child development was evaluated as a major outcome in an open-label, randomized, clinical trial of anti-malarial chemoprevention in an area of intense, year-round transmission in Uganda. Infants were randomized to one of four treatment arms: no chemoprevention, daily trimethoprim-sulfamethoxazole, monthly sulfadoxine-pyrimethamine, or monthly dihydroartemisinin-piperaquine (DP), to be given between enrollment (4-6 mos) and 24 months of age. Number of malaria episodes, anaemia (Hb < 10) and neurodevelopment [Mullen Scales of Early Learning (MSEL)] were assessed at 2 years (N = 469) and at 3 years of age (N = 453); at enrollment 70 % were HIV-unexposed uninfected (HUU) and 30 % were HIV-exposed uninfected (HEU). DP was highly protective against malaria and anaemia, although trial arm was not associated with MSEL outcomes. Across all treatment arms, episodes of malarial illness were negatively predictive of MSEL cognitive performance both at 2 and 3 years of age (P = 0.02). This relationship was mediated by episodes of anaemia. This regression model was stronger for the HEU than for the HUU cohort. Compared to HUU, HEU was significantly poorer on MSEL receptive language development irrespective of malaria and anaemia (P = 0.01). Malaria with anaemia and HIV exposure are significant risk factors for poor early childhood neurodevelopment in malaria-endemic areas in rural Africa. Because of this, comprehensive and cost/effective intervention is needed for malaria prevention in very young children in these settings. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 22% |
| Uganda | 1 | 11% |
| Spain | 1 | 11% |
| Saudi Arabia | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 172 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 37 | 21% |
| Researcher | 25 | 14% |
| Student > Ph. D. Student | 16 | 9% |
| Student > Bachelor | 9 | 5% |
| Student > Postgraduate | 8 | 5% |
| Other | 24 | 14% |
| Unknown | 54 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 59 | 34% |
| Nursing and Health Professions | 11 | 6% |
| Social Sciences | 9 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Immunology and Microbiology | 5 | 3% |
| Other | 26 | 15% |
| Unknown | 57 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2022.
All research outputs
#6,430,117
of 24,400,706 outputs
Outputs from Malaria Journal
#1,657
of 5,827 outputs
Outputs of similar age
#85,898
of 305,395 outputs
Outputs of similar age from Malaria Journal
#43
of 174 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,395 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 174 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.