Chapter title |
Endocannabinoids
|
---|---|
Chapter number | 2 |
Book title |
Endocannabinoids
|
Published in |
Handbook of experimental pharmacology, January 2015
|
DOI | 10.1007/978-3-319-20825-1_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-920824-4, 978-3-31-920825-1
|
Authors |
Cascio, Maria Grazia, Marini, Pietro, Maria Grazia Cascio, Pietro Marini |
Editors |
Roger G. Pertwee |
Abstract |
Since the discovery of the two cannabinoid receptors, CB1 and CB2, several molecules, commonly defined as endocannabinoids, able to bind to and functionally activate these receptors, have been discovered and characterized. Although the general thought was that the endocannabinoids were mainly derivatives of the n-6 fatty acid arachidonic acid, recent data have shown that also derivatives (ethanolamides) of n-3 fatty acids may be classified as endocannabinoids. Whether the n-3 endocannabinoids follow the same biosynthetic and metabolic routes of the n-6 endocannabinoids is not yet clear and so warrants further investigation. In this review, we describe the primary biosynthetic and metabolic pathways for the two well-established endocannabinoids, anandamide and 2-arachidonoylglycerol. |
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