Title |
Nuclear factor one B ( NFIB ) encodes a subtype-specific tumour suppressor in glioblastoma
|
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Published in |
Oncotarget, April 2016
|
DOI | 10.18632/oncotarget.8720 |
Pubmed ID | |
Authors |
Brett W. Stringer, Jens Bunt, Bryan W. Day, Guy Barry, Paul R. Jamieson, Kathleen S. Ensbey, Zara C. Bruce, Kate Goasdoué, Hélène Vidal, Sara Charmsaz, Fiona M. Smith, Leanne T. Cooper, Michael Piper, Andrew W. Boyd, Linda J. Richards |
Abstract |
Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-STAT3 signalling only in classical and mesenchymal GBM cells, suggesting a mechanism through which NFIB may exert its context-dependent tumour suppressor activity. Finally, NFIB expression can be induced in GBM cells by drug treatment with beneficial effects. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 25% |
Portugal | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 48 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 20% |
Student > Bachelor | 9 | 18% |
Researcher | 6 | 12% |
Student > Master | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Other | 4 | 8% |
Unknown | 13 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 33% |
Agricultural and Biological Sciences | 7 | 14% |
Neuroscience | 6 | 12% |
Medicine and Dentistry | 5 | 10% |
Unspecified | 1 | 2% |
Other | 0 | 0% |
Unknown | 14 | 29% |