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Myocardial T1 maps reflect histological findings in acute and chronic stages of myocarditis in a rat model

Overview of attention for article published in Critical Reviews in Diagnostic Imaging, April 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

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16 X users
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3 Facebook pages

Citations

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21 Dimensions

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48 Mendeley
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1 CiteULike
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Title
Myocardial T1 maps reflect histological findings in acute and chronic stages of myocarditis in a rat model
Published in
Critical Reviews in Diagnostic Imaging, April 2016
DOI 10.1186/s12968-016-0241-6
Pubmed ID
Authors

Sarah Jeuthe, Katharina Wassilew, Darach O h-Ici, Tiago Ferreira da Silva, Frédéric Münch, Felix Berger, Titus Kuehne, Burkert Pieske, Daniel R. Messroghli

Abstract

Cardiovascular magnetic resonance offers both diagnostic and prognostic information in myocarditis. Using an established animal model of myocarditis, the aim of this study was to measure myocardial T1 before the onset, in the acute and in the chronic phases of the disease and to compare its course with histological and immunohistochemistry findings. Male young Lewis rats were immunized with 0.25 mg porcine myocardial myosin into the rear footpads on day 0. Native and contrast-enhanced ECG-triggered cardiac MRI examinations were performed before immunization on day 0 and on days 14, 21 and 35. Left ventricular function, pre- and post- contrast T1 parameters and LGE images were assessed using Small animal look-locker inversion recovery (SALLI). For each of the indicated time points a minimum of 4 rats were randomly sacrificed for pathological investigations including conventional histology (HE and Sirius-Red staining) and immunohistochemistry (CD 68) investigations. All immunized rats developed myocarditis (morbidity 100 %). Histologically we observed increased wall thickness with biventricular macrophage-rich mixed inflammatory infiltrates. All rats with a histologically severe myocarditis showed increased native T1 and decreased post-contrast T1 of the myocardium. The assessment of native T1 and post-contrast T1 allows accurate differentiation between healthy myocardium and myocardium with inflammation and also between the acute and chronic phases of the disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 2%
Germany 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 29%
Other 7 15%
Student > Bachelor 4 8%
Student > Master 4 8%
Student > Doctoral Student 3 6%
Other 10 21%
Unknown 6 13%
Readers by discipline Count As %
Medicine and Dentistry 28 58%
Physics and Astronomy 2 4%
Business, Management and Accounting 1 2%
Nursing and Health Professions 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 3 6%
Unknown 12 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2016.
All research outputs
#3,783,479
of 25,522,520 outputs
Outputs from Critical Reviews in Diagnostic Imaging
#219
of 1,379 outputs
Outputs of similar age
#56,046
of 297,390 outputs
Outputs of similar age from Critical Reviews in Diagnostic Imaging
#3
of 22 outputs
Altmetric has tracked 25,522,520 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,379 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,390 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.