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Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates

Overview of attention for article published in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], March 2015
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Title
Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
Published in
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], March 2015
DOI 10.1590/s1517-838246120120442
Pubmed ID
Authors

Denardi, Laura Bedin, Mario, Débora Alves Nunes, Loreto, Érico Silva, Santurio, Janio Morais, Alves, Sydney Hartz

Abstract

In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata , a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro , notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies.

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Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Other 5 17%
Student > Doctoral Student 4 14%
Student > Bachelor 4 14%
Student > Ph. D. Student 3 10%
Other 6 21%
Unknown 2 7%
Readers by discipline Count As %
Immunology and Microbiology 8 28%
Medicine and Dentistry 7 24%
Agricultural and Biological Sciences 3 10%
Unspecified 2 7%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 7%
Unknown 6 21%