Title |
Antistaphylococcal activity of bacteriophage derived chimeric protein P128
|
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Published in |
BMC Microbiology, March 2012
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DOI | 10.1186/1471-2180-12-41 |
Pubmed ID | |
Authors |
Aradhana A Vipra, Srividya Narayanamurthy Desai, Panchali Roy, Raghu Patil, Juliet Mohan Raj, Nagalakshmi Narasimhaswamy, Vivek Daniel Paul, Ravisha Chikkamadaiah, Bharathi Sriram |
Abstract |
Bacterial drug resistance is one of the most significant challenges to human health today. In particular, effective antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) are urgently needed. A causal relationship between nasal commensal S. aureus and infection has been reported. Accordingly, elimination of nasal S. aureus reduces the risk of infection. Enzymes that degrade bacterial cell walls show promise as antibacterial agents. Bacteriophage-encoded bacterial cell wall-degrading enzymes exhibit intrinsic bactericidal activity. P128 is a chimeric protein that combines the lethal activity of the phage tail-associated muralytic enzyme of Phage K and the staphylococcal cell wall targeting-domain (SH3b) of lysostaphin.Here we report results of in vitro studies evaluating the susceptibility of staphylococcal strains to this novel protein. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Nepal | 1 | 1% |
India | 1 | 1% |
Unknown | 72 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 17% |
Researcher | 12 | 16% |
Student > Ph. D. Student | 12 | 16% |
Student > Bachelor | 8 | 11% |
Other | 5 | 7% |
Other | 12 | 16% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 35% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Immunology and Microbiology | 5 | 7% |
Veterinary Science and Veterinary Medicine | 2 | 3% |
Other | 7 | 9% |
Unknown | 16 | 21% |