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The protamine family of sperm nuclear proteins

Overview of attention for article published in Genome Biology (Online Edition), January 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

1 blog
2 tweeters
1 Wikipedia page


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Readers on

379 Mendeley
1 CiteULike
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The protamine family of sperm nuclear proteins
Published in
Genome Biology (Online Edition), January 2007
DOI 10.1186/gb-2007-8-9-227
Pubmed ID

Rod Balhorn


The protamines are a diverse family of small arginine-rich proteins that are synthesized in the late-stage spermatids of many animals and plants and bind to DNA, condensing the spermatid genome into a genetically inactive state. Vertebrates have from one to 15 protamine genes per haploid genome, which are clustered together on the same chromosome. Comparison of protamine gene and amino-acid sequences suggests that the family evolved from specialized histones through protamine-like proteins to the true protamines. Structural elements present in all true protamines are a series of arginine-rich DNA-anchoring domains (often containing a mixture of arginine and lysine residues in non-mammalian protamines) and multiple phosphorylation sites. The two protamines found in mammals, P1 and P2, are the most widely studied. P1 packages sperm DNA in all mammals, whereas protamine P2 is present only in the sperm of primates, many rodents and a subset of other placental mammals. P2, but not P1, is synthesized as a precursor that undergoes proteolytic processing after binding to DNA and also binds a zinc atom, the function of which is not known. P1 and P2 are phosphorylated soon after their synthesis, but after binding to DNA most of the phosphate groups are removed and cysteine residues are oxidized, forming disulfide bridges that link the protamines together. Both P1 and P2 have been shown to be required for normal sperm function in primates and many rodents.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 379 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
France 3 <1%
Japan 2 <1%
Denmark 2 <1%
United Kingdom 2 <1%
Canada 1 <1%
Mexico 1 <1%
India 1 <1%
Russia 1 <1%
Other 3 <1%
Unknown 357 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 114 30%
Student > Master 62 16%
Researcher 61 16%
Student > Bachelor 43 11%
Student > Doctoral Student 23 6%
Other 50 13%
Unknown 26 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 169 45%
Biochemistry, Genetics and Molecular Biology 81 21%
Medicine and Dentistry 32 8%
Chemistry 15 4%
Pharmacology, Toxicology and Pharmaceutical Science 11 3%
Other 37 10%
Unknown 34 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2014.
All research outputs
of 12,486,858 outputs
Outputs from Genome Biology (Online Edition)
of 2,835 outputs
Outputs of similar age
of 117,679 outputs
Outputs of similar age from Genome Biology (Online Edition)
of 16 outputs
Altmetric has tracked 12,486,858 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,835 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.