Chapter title |
Vaccine Design
|
---|---|
Chapter number | 29 |
Book title |
Vaccine Design
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3387-7_29 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3385-3, 978-1-4939-3387-7
|
Authors |
Thomas, Sunil, Sunil Thomas |
Editors |
Sunil Thomas |
Abstract |
The obligate intracellular bacterium Ehrlichia chaffeensis that resides in mononuclear phagocytes is the etiologic agent of human monocytotropic ehrlichiosis (HME). HME is an emerging and often life-threatening zoonotic, tick-transmitted infectious disease in the USA. Lack of early diagnosis and treatment of HME are the main factors that lead to severe and fatal disease. Ehrlichia also causes diseases in companion animals and domesticated ruminants. E. chaffeensis and E. canis cause canine ehrlichioses in dogs, whereas E. ruminantium causes heartwater in cattle, sheep, and goats. As yet there are no commercially available vaccines to protect against these pathogens. This chapter describes a protocol to develop a structure-based vaccine for Ehrlichia based on the antigenic proteins P28-19 and Ehrlichia Hsp60. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 10% |
Unknown | 9 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 20% |
Student > Doctoral Student | 2 | 20% |
Other | 1 | 10% |
Student > Master | 1 | 10% |
Unknown | 4 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Agricultural and Biological Sciences | 2 | 20% |
Nursing and Health Professions | 1 | 10% |
Veterinary Science and Veterinary Medicine | 1 | 10% |
Unknown | 4 | 40% |