Chapter title |
Vaccine Design
|
---|---|
Chapter number | 44 |
Book title |
Vaccine Design
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3387-7_44 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3385-3, 978-1-4939-3387-7
|
Authors |
Sabado, Rachel Lubong, Meseck, Marcia, Bhardwaj, Nina, Rachel Lubong Sabado, Marcia Meseck, Nina Bhardwaj |
Editors |
Sunil Thomas |
Abstract |
Exploitation of the patient's own immune system to induce antitumor immune responses using dendritic cell (DC) immunotherapy has been established in early clinical trials as a safe and promising therapeutic approach for cancer. However, their limited success in larger clinical trials highlights the need to optimize DC vaccine preparations. This chapter describes the methodologies utilized for the preparation of the DC vaccine most commonly used in clinical trials. Optional variations at different stages in DC vaccine preparation, based on the nature of antigen, delivery of antigen, maturation stimuli, and mode of administration for DC vaccines, are also presented for consideration as these are often dependent on the disease setting, desired immune response, and/or resources available. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 44 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 17% |
Student > Bachelor | 6 | 13% |
Other | 6 | 13% |
Researcher | 6 | 13% |
Student > Master | 4 | 9% |
Other | 6 | 13% |
Unknown | 10 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 26% |
Agricultural and Biological Sciences | 10 | 22% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Immunology and Microbiology | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 4 | 9% |
Unknown | 10 | 22% |