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Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

Overview of attention for article published in Journal of Biological Chemistry, April 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

blogs
1 blog
twitter
6 tweeters
wikipedia
1 Wikipedia page

Readers on

mendeley
42 Mendeley
citeulike
1 CiteULike
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Title
Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates
Published in
Journal of Biological Chemistry, April 2012
DOI 10.1074/jbc.m112.355958
Pubmed ID
Authors

Ilan Margalith, Carlo Suter, Boris Ballmer, Petra Schwarz, Cinzia Tiberi, Tiziana Sonati, Jeppe Falsig, Sofie Nyström, Per Hammarström, Andreas Åslund, K. Peter R. Nilsson, Alice Yam, Eric Whitters, Simone Hornemann, Adriano Aguzzi, Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nystrom S, Hammarstrom P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A

Abstract

Luminescent conjugated polymers (LCPs) interact with ordered protein aggregates and sensitively detect amyloids of many different proteins, suggesting that they may possess antiprion properties. Here, we show that a variety of anionic, cationic, and zwitterionic LCPs reduced the infectivity of prion-containing brain homogenates and of prion-infected cerebellar organotypic cultured slices and decreased the amount of scrapie isoform of PrP(C) (PrP(Sc)) oligomers that could be captured in an avidity assay. Paradoxically, treatment enhanced the resistance of PrP(Sc) to proteolysis, triggered the compaction, and enhanced the resistance to proteolysis of recombinant mouse PrP(23-231) fibers. These results suggest that LCPs act as antiprion agents by transitioning PrP aggregates into structures with reduced frangibility. Moreover, ELISA on cerebellar organotypic cultured slices and in vitro conversion assays with mouse PrP(23-231) indicated that poly(thiophene-3-acetic acid) may additionally interfere with the generation of PrP(Sc) by stabilizing the conformation of PrP(C) or of a transition intermediate. Therefore, LCPs represent a novel class of antiprion agents whose mode of action appears to rely on hyperstabilization, rather than destabilization, of PrP(Sc) deposits.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Portugal 1 2%
United States 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 29%
Student > Ph. D. Student 11 26%
Student > Master 6 14%
Student > Bachelor 5 12%
Professor 3 7%
Other 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 43%
Biochemistry, Genetics and Molecular Biology 8 19%
Chemistry 8 19%
Medicine and Dentistry 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#699,839
of 8,761,118 outputs
Outputs from Journal of Biological Chemistry
#610
of 31,204 outputs
Outputs of similar age
#6,949
of 94,822 outputs
Outputs of similar age from Journal of Biological Chemistry
#4
of 171 outputs
Altmetric has tracked 8,761,118 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,204 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,822 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.